Tilley Group

“I believe that answering the major medical and biotechnology questions of the 21st century will require convergence of the life and physical sciences and reliance on the use of advanced imaging techniques.” – Leann Tilley

Research

Every minute, one child in Africa dies from malaria. Around the world, the mosquito-borne parasite kills about 600,000 people each year, most of them children and pregnant women, while another 200 million people suffer illness as a result of malaria infections.

Carried by the anopheles mosquito, the tiny malaria parasite invades the victim's red blood cells where it starts devouring the red cell haemoglobin and changing the cells so that the infected red blood cells stick to blood vessel walls. This leads to the typical symptoms of fever and headaches, but in severe cases results in coma and death.

The Tilley lab is working as part of a global effort to understand and control malaria. We undertake research in the areas of cell biology and drug development related to the malaria parasite, Plasmodium falciparum. We are particularly interested in how the parasite alters the erythrocyte surface to cause malaria pathology, as well as the remarkable transformation that turns parasites crescent-shaped and allows them to be transmitted from a human host to a mosquito vector. We also investigate the action of and resistance to artemisinin, with a view to designing better antimalarial drugs.

Techniques

As part of this collaboration, Leann’s laboratory helped to develop and implement a number of new imaging modalities and apply them in pioneering applications. Such modalities include coherent X-ray diffraction Imaging, 3D electron tomography, cryo x-ray tomography, and structured illumination microscopy.

Leann is a major user of the Advanced Microscopy Facility at the Bio21 Institute and is involved in efforts to strengthen capabilities in microscopy through the Cellular NanoImaging Consortium and the Victorian Microscopy Network.

Group Members

Group Head

Professor Leann Tilley

Postdoctoral Fellows

Matt Dixon
Nick Klonis
Susi Herrmann

Research Assistant

Shannon Kenny

Graduate students

Emma McHugh
Jess Bridgford
Laure Dumont
Oliver Looker
Stanley (Cheng) Xie
Steven Batinovic
Tuo Yang

Honours student

Annika Suttie

Biography

Leann Tilley obtained her BSc(Hons) in Biochemistry from the University of Melbourne, and her PhD in Biochemistry from the University of Sydney. After postdoctoral fellowships at Utrecht University in the Netherlands, the College de France in Paris, and at the University of Melbourne, she joined the Biochemistry Department at La Trobe University. In July 2011 she returned to the Department of Biochemistry and Molecular Biology at the University of Melbourne.

Professor Tilley holds an ARC Australian Professorial Fellowship and a Georgina Sweet Australian Laureate Fellowship . Her work has been recognised by the award of the Bancroft-Mackerras Medal from the Australian Society for Parasitology (2010) and the Beckman Coulter Discovery Award of the Australian Society for Biochemistry and Molecular Biology (2011).

Leann embraces a large range of technologies from drug and protein chemistry to molecular cell biology and novel imaging technologies. She is assisted by collaborations with experts from other disciplines, ranging from molecular parasitologists to organic chemists and optical physicists.

Leann served as Deputy Director and Director of the ARC Centre of Excellence for Coherent X-ray Science (CXS) (2006-2014). This Centre brought physicists, chemists and biologists together to develop fundamentally new approaches to probing biological structures and processes. It received international acclaim for its cross-disciplinary and cross-institutional work and its contributions to the development of novel imaging techniques.