Bio21 Molecular Science & Biotechnology Institute - Bio21 https://www.bio21.unimelb.edu.au/tags/bio21 en NHMRC project grants and fellowships reflect strength of Bio21 research https://www.bio21.unimelb.edu.au/nhmrc-project-grants-and-fellowships-reflect-strength-bio21-research <div class="field field-name-field-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img typeof="foaf:Image" src="https://www.bio21.unimelb.edu.au/sites/www.bio21.unimelb.edu.au/files/styles/page/public/field/image/2016-12-09-Bio21_NHMRC-announcement.jpg?itok=4oo-_U81" width="960" height="440" alt="" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p><a href="https://www.nhmrc.gov.au/grants-funding/outcomes-funding-rounds">The NHMRC announced the results of the 2017 NHMRC project grant round on 3 December 2016</a>.</p> <p>Congratulations to the following Bio21 members on their success in this round.</p> <h3>Project grants</h3> <p>Michael Duffy, $689,034 over 3 years: "The role of novel and essential bromodomain proteins in coordinating malaria parasite gene regulation and their potential as anti-malarial targets"</p> <p>Greg Moseley, Spencer Williams, Paul Gooley, $900,994 over 4 years: "Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis"</p> <p>Marie Bogoyevitch, $755,190 over 3 years: "Altered nuclear trafficking and nuclear body dynamics as drivers of ataxin-1 toxicity"</p> <p>Angus Johnston and Justine Mintern, $553,152 over 3 years: " Improving therapeutic delivery by understanding nanparticle interactions with cells” Eric Reynolds: $831 656 over 4 years for the project: "Characterization of the Type IX secretion system in Porphyromonas gingivalis"</p> <p>Malcolm McConville: $531 114 over 3 years: "Targeting acute and chronic toxoplasmosis"</p> <p>Anthony White and Paul Donnelly: $458,937 over 3 years: 'Building an immunocompetent Alzheimer disease brain-on-a-chip’</p> <h3>Research Fellowships</h3> <p>I would also like to congratulate Professors Ary Hoffman and Michael Parker on their successful award/renewal to their NHMRC Research Fellowships.</p> <p>Ary Hoffmann, $763 845: "Enhancing disease vector biosecurity through high density molecular markers.”</p> <p>Michael Parker, $863,910: “Structural Biology"</p> <p>In a such a competitive funding environment, it is terrific to see these successes which reflects the strong research environment in the Institute.</p> </div></div></div> Wed, 07 Dec 2016 02:53:27 +0000 floder 231 at https://www.bio21.unimelb.edu.au ARC funds Bio21 projects, researchers and infrastructure https://www.bio21.unimelb.edu.au/arc-funds-bio21-projects-researchers-and-infrastructure <div class="field field-name-field-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img typeof="foaf:Image" src="https://www.bio21.unimelb.edu.au/sites/www.bio21.unimelb.edu.au/files/styles/page/public/field/image/2016-11-11-Bio21-News_ARC-success_portraits_2.jpg?itok=F-2hWpXw" width="960" height="440" alt="" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>2 November 2016</p> <p>Congratulations to members of the Bio21 Institute who were successful in the <a href="http://www.arc.gov.au/november-2016-arc-major-grants-announcement">ARC Discovery Project, LIEF and Discovery Early Career Research Award grant funding schemes this year</a>.</p> <p>In results announced today, Bio21 groups were awarded $2.34 million in Discovery Project funding and also led or were involved in five successful LIEF grants which received $4.12 million in ARC funding.</p> <p>Two Bio21 early career researchers were also awarded $732,000 with DECRA fellowships.</p> <p>This success has occurred in a very competitive environment and will ensure continuity of key staff and research programs for many groups, as well as major investments in the institute’s leading technology platforms.</p> <p>For the Bio21 Institute, it indicates a highly vibrant and collaborative research culture and reinforces the institute’s status as a hub of excellence in molecular and biotechnology research.</p> <p>Bio21 researchers were awarded the following grants:</p> <h3>Discovery Early Career Researcher Award:</h3> <p>Dr Hamish McWilliam (Villadangos lab), to study the role of a host molecule in immune protection, $372,000 over 3 years.</p> <p>Dr Brett Paterson (Donnelly lab), to produce homogeneous and fully functional constructs that may be used as imaging agents, $360,000 over 3 years.</p> <h3>ARC Discovery Project:</h3> <p>Dr Michael Griffin (DP170104046) The early structural assembly of high-density lipoproteins $379,000 over 3 years.</p> <p>Associate Professor Daniel Hatters &amp; Professor Gavin Reid (DP170103093) Surveillance of the mechanisms controlling proteome foldedness, $466,500 over 3 years.</p> <p>Prof Jose Villadangos (DP170102471) A mechanism for pathogen detection highly conserved in mammals, $513, 500 over 3 years.</p> <p>Dr Diana Stojanovski; Dr Dedreia Tull; Professor Thomas Langer (DP170101249) Mitochondrial biogenesis in mammalian cells, $380,500 over 3 years.</p> <p>Associate Professor Uta Wille; Professor Richard O’Hair (DP1700100035)Environmental polymer degradation, $286,000 over 3 years.</p> <p>Professor Edmund Crampin; Dr Vijay Rajagopal; Professor Dr Hywel Roderick; Professor Christian Soeller (DP170101358) How calcium makes the heart grow, $316,000 over 3 years.</p> <h3>LIEF grants:</h3> <p>Professor Michael Parker; Professor James Whisstock; Professor Leann Tilley; Associate Professor Eric Hanssen; Professor Frances Separovic; Professor Jamie Rossjohn; Associate Professor Max Cryle; Professor Juliet Gerrard; Associate Professor Hans Elmlund; Professor Alan Cowman; Dr Daniela Stock; Professor Ricky Johnstone; Dr Lawrence Lee; Associate Professor Paul Ramsland; Professor Robert Pike. LE170100016 - a collaborative electron microscopy network for structural biology. $850,000.</p> <p>Professor Jonathan White; Dr Michael Griffin; Associate Professor Colette Boskovic; Dr Peter Barnard; Dr Jason Dutton; Dr David Turner; Professor Philip Andrews; Dr Christopher Ritchie; Professor Cameron Jones; Associate Professor Brendan Abrahams; Eminent Professor Keith Murray; Professor Stuart Batten - LE170100065 - Molecular Structure Elucidation Facility. $830,000.</p> <p>Professor Justin Zobel; Professor Michael Parker; Professor Andrew Ooi; Professor Richard Sandberg; Associate Professor Andrew Lonie; Professor Salvy Russo; Professor Toby Allen; Professor Irene Yarovsky; Professor Tiffany Walsh; Professor John Grundy; Professor Maria Forsyth; Professor Brian Smith - LE170100200 A high-performance cloud resource for computational modelling. $640,000</p> <p>Professor Paul Mulvaney and Bio21 contributed to LE170100118 led by Monash University. UltraTEM: Resolving the structure of matter in space, energy and time. $1.8M.</p> </div></div></div> Fri, 11 Nov 2016 03:19:00 +0000 floder 228 at https://www.bio21.unimelb.edu.au There’s work (and life) outside of universities for PhD graduates https://www.bio21.unimelb.edu.au/there%E2%80%99s-work-and-life-outside-universities-phd-graduates <div class="field field-name-field-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img typeof="foaf:Image" src="https://www.bio21.unimelb.edu.au/sites/www.bio21.unimelb.edu.au/files/styles/page/public/field/image/2015-07-21_Bio21-Events_Big-Picture-Andrew-Holmes_web_Casamento_1.jpg?itok=wFAjg1-i" width="960" height="440" alt="" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>4 August 2016</p> <p><span><a href="https://theconversation.com/profiles/les-field-101362">Les Field</a>, <em><a href="http://theconversation.com/institutions/unsw-australia">UNSW Australia</a></em> and <a href="https://theconversation.com/profiles/andrew-holmes-113839">Andrew Holmes</a>, <em><a href="http://theconversation.com/institutions/university-of-melbourne">University of Melbourne</a></em></span></p> <p>The number of PhD students graduating from Australian universities continues to rise, with <a href="https://docs.education.gov.au/documents/2014-award-course-completions">more than 8,000 in 2014</a> and about one in three in science, technology, engineering and mathematics (STEM) disciplines.</p> <p>Our best estimates are that about half of these students will begin an academic career as postdoctoral research fellows or research assistants.</p> <p>But over time most will move out of – and much less frequently back into – academic jobs.</p> <p>Only around 2% of PhD graduates are expected to reach professorial levels and enjoy the privilege of an <a href="https://royalsociety.org/~/media/Royal_Society_Content/policy/publications/2010/4294970126.pdf">uninterrupted academic career</a>.</p> <h2>Options and expectations</h2> <p>Most PhD graduates are driven by a passion for their field and commit years to study. Some are sold on the promise that they will one day have an independent research career, like their supervisors.</p> <p>The reality of fierce competition for grants, intense pressure to perform, inflexible funding regulations and 12-month contracts is often <a href="http://www.abc.net.au/radionational/programs/scienceshow/the-perilous-road-for-graduating-phds/7652818">a stark and unwelcome revelation</a>.</p> <p>But the modern PhD is not only a training to conduct specialised research. It is also a wider preparation for diverse employment.</p> <p>A PhD equips people with the ability to think critically, to assess a problem in the context of the wider body of knowledge, and to produce original solutions independently. It also gives them the ability to communicate and articulate solutions.</p> <p>Irrespective of whether they find careers in academia, graduates with STEM PhDs are more likely to be employed and <a href="http://acola.org.au/PDF/SAF13/SAF13%20RTS%20report.pdf">will earn higher salaries</a> than bachelors and higher-degree graduates from most other disciplines within five years of graduation.</p> <p>This is seen by those in government as a positive for the economy. People with STEM PhDs are increasingly seen by employers in government, industry and the community sector as some of the best generalist graduates on the market.</p> <p>So we need to do more to help PhD students understand that their training opens up a wide range of possibilities, with academic research being just one, and we need to support PhD students to explore what fits best for them.</p> <p>We need better enrolment processes, supervision, skills development and internship opportunities. That way our most highly trained graduates would be better prepared to embrace the many opportunities that a PhD will bring.</p> <h2>For those who stay in academia</h2> <p>One key issue we need to address is how to plan for and achieve a healthy balance of senior, junior and mid-career researchers across the disciplines. We need to do this with equal opportunities for men, women and those from diverse groups to nurture a healthy pipeline of talented new scientists for the future.</p> <p>But both the National Health and Medical Research Council (<a href="https://www.nhmrc.gov.au/">NHMRC</a>) and the Australian Research Council (<a href="http://www.arc.gov.au/">ARC</a>) have struggled to develop schemes that build and nurture research careers while simultaneously supporting proposals judged by peer-review to be the best and most worthwhile research ideas.</p> <p>One scheme that has changed the game to an extent is the <a href="http://www.arc.gov.au/future-fellowships">ARC Future Fellowship</a> scheme. The Academy of Science <a href="https://www.science.org.au/supporting-science/science-policy/submissions-government/response%E2%80%94arc-future-fellowships">advocated strongly and instrumentally for</a> prior to its establishment in 2009, and for its continuation when <a href="https://theconversation.com/if-we-want-to-be-a-smart-nation-we-should-keep-future-fellowships-39323">threatened by budget cuts</a> more recently.</p> <p>But with funding for just 100 Future Fellowships each year, this scheme is only a drop in the ocean. There is clearly much to be done.</p> <h2>Investing in capability</h2> <p>Australia is starting to recognise that to be a successful player in the world economy we do need to move into the innovation age. Prime Minister Malcolm Turnbull’s <a href="https://theconversation.com/turnbull-seeks-ideas-boom-with-innovation-agenda-experts-react-51892">National Innovation and Science Agenda</a>, released last year, started that process.</p> <p>Many have argued Australia needs to <a href="http://www.smh.com.au/business/federal-budget/federal-budget-scientists-push-for-more-research-funding-20160411-go3uaa.html">invest about 3% of GDP</a> in science and research to be on par with countries which have strong and successful innovation performance.</p> <p>To achieve this, Australia would have to commit in the order of A$5 billion a year of additional public funding of research to leverage an additional A$10 billion a year in industry research and development. This is not an easy task and not something that will happen quickly.</p> <p>Only when there is a firm commitment to investing in the research sector can the focus shift to building capacity in the longer term.</p> <p>But the financial quadrant of government (and the industry sector) is often reluctant to make longer-term commitments, and wherever possible tends to retreat to short term programs because this maximises the flexibility to shift resources in response to the demands of the day.</p> <p>The message that we need to reinforce is that good research is not done in little bites. Moving away from an environment where short-term funding cycles for research are the norm and towards a framework which commits to larger, deeper and longer-term programs would instantly provide a vehicle in which career structures for researchers can be embedded.</p> <h2>Review of research training</h2> <p>Looking at research training itself, we need to make sure the many thousands of PhD graduates produced each year are both better prepared for (and less shocked by) the reality that many will end up working in government or industry, and not in academia.</p> <p>There is also a need to help students to attain and/or recognise their transferable skills. Industry, government or community sector placements can both expose students to those opportunities and to employer needs outside of academia. It also shows to employers the skill sets of PhD graduates.</p> <p>We need to do more both to support and encourage the most intellectually and experimentally capable scientists at all levels to flourish in the research sector. That way we better prepare our most highly-trained graduates to contribute to society through a variety of rewarding occupations and careers, outside of academia.</p> <p><img alt="The Conversation" height="1" src="https://counter.theconversation.edu.au/content/63401/count.gif" width="1" /></p> <p><span><a href="https://theconversation.com/profiles/les-field-101362">Les Field</a>, Secretary for Science Policy at the Australian Academy of Science, and Senior Deputy Vice-Chancellor, <em><a href="http://theconversation.com/institutions/unsw-australia">UNSW Australia</a></em> and <a href="https://theconversation.com/profiles/andrew-holmes-113839">Andrew Holmes</a>, President of the Australian Academy of Science, Laureate Professor Emeritus, <em><a href="http://theconversation.com/institutions/university-of-melbourne">University of Melbourne</a></em></span></p> <p>This article was originally published on <a href="http://theconversation.com">The Conversation</a>. Read the <a href="https://theconversation.com/theres-work-and-life-outside-of-universities-for-phd-graduates-63401">original article</a>.</p> </div></div></div> Tue, 16 Aug 2016 00:00:58 +0000 floder 211 at https://www.bio21.unimelb.edu.au Researching Research - A week of work experience at Bio21 https://www.bio21.unimelb.edu.au/researching-research-week-work-experience-bio21 <div class="field field-name-field-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img typeof="foaf:Image" src="https://www.bio21.unimelb.edu.au/sites/www.bio21.unimelb.edu.au/files/styles/page/public/field/image/2016-07-06-Bio21News_Work-Experience_web.jpg?itok=4PybYfZ8" width="960" height="440" alt="" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>1 July 2016</p> <p>By Kevin Cheung and Zara Tse, Year 10 work experience students, Bio21</p> <p>Yes, those random people you saw at Bio21 last week were high school students on work experience. From the 27<sup>th</sup> June to the 1<sup>st</sup> July a group of ten high school students from around the state converged on the Institute to engage in a week of work experience. From the NMR cave to the various laboratories around the Institute, the students managed to clog elevators, crowd couches in the café and tried to learn about the ins and outs of your research.</p> <p>Students have been bombarded with knowledge and insights that they will forever retain. Exclamations of ‘wow’ and what?’ were common phrases in their time here. A collaborative appreciation of complexity was found among the students, with the NMR reading throwing everyone into deep thought. Inconclusive results regarding <em>Leishmania</em> cultures (most likely due to poor experimental technique) and surprising bacterial cultures from mouth samples kept the students, covered in laboratory coats and safety glasses, on their toes. We’re all grateful for this opportunity to witness your work and thankful to you for allowing us in and taking the time to explain your roles to us.</p> <p>You have left a resounding impact on us students; an impact that will last for months, if not years to come.</p> <p> </p> </div></div></div> Wed, 06 Jul 2016 07:12:23 +0000 floder 204 at https://www.bio21.unimelb.edu.au Vibrant Research Culture Sows Seeds for Discovery https://www.bio21.unimelb.edu.au/vibrant-research-culture-sows-seeds-discovery <div class="field field-name-field-image field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img typeof="foaf:Image" src="https://www.bio21.unimelb.edu.au/sites/www.bio21.unimelb.edu.au/files/styles/page/public/field/image/2015-11-02-Bio21News_ARC-Success_web.jpg?itok=MGrgKqw9" width="960" height="440" alt="" /></div></div></div><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>In results announced on Friday, 30 October 2015, Bio21 Molecular Science and Biotechnology Institute research groups were awarded nearly $7 million ($6,226,200) in Discovery Project (DP) funding.</p> <p>Consortia led by Bio21 researchers were also awarded three LIEF grants.</p> <p>In total, Bio21 researchers were awarded a total of $7,573,700 across 15 successful grants. This success has occurred under extremely competitive conditions.</p> <p>“This funding will ensure continuity of key staff and research programs in many groups. For the Bio21 Institute, it indicates a highly vibrant and collaborative research culture and reinforces the institute’s status as a hub of excellence in molecular and biotechnology research,” said Bio21 Institute Director, Professor Malcolm McConville.</p> <p>“This is an outstanding result.  A perfect year to have this hit being the 10 year anniversary.  I think the success reflects the breadth of the research environment of Bio21 and the quality of researchers.  Multi-disciplinary environments take a while to mature, but now we’re reaping the rewards,” said Professor Paul Gleeson, Head of the Department of Biochemistry, University of Melbourne.</p> <p>The ARC Discovery grants support a breadth of research fields, from the development of solar cell technology, understanding the immune system, to ensuring the survival of endangered species in the face of climate change.</p> <p>"We are delighted with this support from the ARC. There is growing recognition that sunlight provides the simplest source of renewable energy. A team of chemists and engineers at the University of Melbourne and Monash University believe that there is room to drastically improve current solar cells by careful modification of the solar cell surfaces and interfaces. The ARC funds will enable us to test this idea. These results continue to help position Australia as a global leader in solar energy research. We attribute our success in this highly competitive funding system to the strong infrastructure offered by the Bio21 Institute and New Horizons buildings at Melbourne and Monash respectively, " said Professor Paul Mulvaney.</p> <p>“This grant will support a major four year program that will seek to understand the repertoire of microbial lipidic species that elicit innate immune responses. The work will enrich our understanding of how our body responds to infections and maintains stable populations of beneficial microbes within our gut microbiota,” said Professor Spencer Williams.</p> <p><u>ARC Discovery Grants:</u></p> <p>Professor <a href="/batterham-group">Phil Batterham</a> to receive $369,600 over three years to study nicotinic acetylcholine receptors that are targeted by insecticides used to control the major pests that afflict agriculture and domestic pets.</p> <p>Associate Professor Bogoyevitch to receive $388,800 over three years to examine new regulatory mechanisms for an important signalling enzyme in the cell nucleus.</p> <p>Dr <a href="/donnelly-group">Paul Donnelly</a> to receive $377,600 over three years to develop new synthetic coordination chemistry for making new copper and technetium complexes to assist in the diagnosis of neurodegeneration.</p> <p>Professor <a href="/gleeson-group">Paul Gleeson t</a>o receive $471,500 over three years to determine the function of the Golgi ribbon structure in higher order cell functions, including metabolism, cell cycle, and cell polarity in both cultured cells and whole organisms.</p> <p>Professor <a href="/hoffmann-group">Ary Hoffmann</a> and Andrew Weeks to receive $342,300 for three years to evaluate a promising but rarely used method of population recovery by genetically rescuing populations of two threatened Australian mammals: the mountain pygmy possum and the eastern barred bandicoot.</p> <p>Associate Professor Michael Kearney and Professor<a href="/hoffmann-group"> Ary Hoffmann</a> to receive $360,800 over three years to characterise and predict the responses of invertebrates to climate variability and climate change, in particular investigating the phenomenon of ‘diapause’.</p> <p>Professor <a href="/mulvaney-group">Paul Mulvaney</a> to receive $687,000 over three years to explore the potential of self-assembled dipole layers (molecular and inorganic) as a mechanism for separating charge carriers at semiconductor surfaces, to ultimately design more efficient solar cells and other light-harvesting molecular systems.</p> <p>Professor <a href="/mulvaney-group">Paul Mulvaney</a> and colleagues to receive $770,000 over five years to develop new technology, to enable simultaneous measurement of the mass and conformation of single molecules.</p> <p>Professor <a href="/michael-parker">Michael Parker</a> to receive $620,500 over five years to unravel missing molecular details of how a major superfamily of proteins is able to drill holes in cell membranes to provide fundamental insights in understanding vital physiological processes across all kingdoms of life to engineer membrane pores as highly specific sensors for a variety of molecules with nanotechnology and biotechnology applications.</p> <p>Professor<a href="/reynolds-group"> Eric Reynolds</a> and colleagues to receive $491,100 over three years to develop a new platform technology for the development of antimicrobial agents by combining expertise in polymer science and antimicrobial studies.</p> <p>Dr <a href="/ralph-group">Stuart Ralph</a> and colleagues to receive $336,400 over three years to provide a detailed picture of how alternative splicing is regulated in four biologically diverse apicomplexan parasites, and to explain why parasites need this molecular trick to survive.</p> <p>Professor <a href="/separovic-group">Frances Separovic</a> to receive $377,600 over three years to develop methods to determine the detailed structure of biologically important molecules in live cells to better understand how biomolecular structure is related to disease.</p> <p>Professor <a href="/villadangos-group">Jose Villadangos</a> to receive $633,000 over three years to understand how a family of enzymes called MARCHs regulate expression and localisation of immunoregulatory receptors within cells by post-translational addition of a small protein tag called Ubiquitin.</p> <p>Associate Professor <a href="/content/williams-group">Spencer Williams</a> to receive $631,626 over four years to develop new approaches to chemically synthesise bacterial and fungal glycolipids and develop a molecular-level understanding of their effect on the immune system.</p> <p><u>LIEF grants:</u></p> <p>$500,000.00 awarded to Bio21 researchers Professor <a href="/reid">Gavin Reid</a>, Professor <a href="/mcconville-group">Malcolm McConville</a>, Dr <a href="/mass-spectrometry-and-proteomics">Nicholas Williamson</a> and colleagues for the acquisition of an ultra-high-resolution mass spectrometry facility for lipidomics research.</p> <p>$800,000.00 awarded to Bio21 researchers Professor<a href="/separovic-group"> Frances Separovic</a>, Dr Marco Sani and Dr <a href="/magnetic-resonance">David Keizer</a> for the acquisition of a dynamic nuclear polarisation system for molecular structure determination.</p> <p>Dr <a href="/ian-holmes-imaging-centre">Paul McMillan</a> and colleagues were awarded $347,500 to expand the current super-resolution confocal microscopy facility.</p> <p>The Dean of Science, Professor Karen Day, was delighted to congratulate the recipients of the various grants;</p> <p class="rteindent1">I’d like to acknowledge the work of those academics who acted as mentors, read grants and provided their own successful applications for review and also to Nicola Pressling who was instrumental in developing a mentor scheme for the DECRA applicants and arranging mock ARC review panels for DP applicants. This approach has clearly paid off and is a strategy the Faculty will continue to adopt to maximise our success in major grant schemes.    </p> <p>Professor Day also acknowledged that those who were not successful in the DP round, that 7 applicants were ranked in the top 10% unsuccessful applications and further 9 in the top 10-25%. The Faculty will announce plans for its “near-miss grants” scheme in mid-Nov and some of these applicants will be eligible to apply for funding. </p> <p>By <a href="/engage">Florienne Loder, External Relations Officer, Bio21</a></p> </div></div></div> Mon, 02 Nov 2015 00:47:53 +0000 floder 157 at https://www.bio21.unimelb.edu.au